Introduction.-Molecular biology of lentivirus-mediated gene transfer.-HIV-derived lentiviral vectors.-SIV-derived lentiviral vectors.-Non-primate lentiviral vectors.-Production of lentiviral vectors.-Biosafety issues in lentiviral vector production.-Lentiviral vector targeting.-Integration site selection by lentiviruses: biology and possible control.-Improving the posttranscriptional aspects of lentiviral vectors.- Lentiviruses as vectors for CNS diseases.-Lentiviral vectors for the gene therapy of lympho-hematological disorders.-Lentiviral vectors for gene therapy of HIV-induced disease.-Opportunities for the use of lentiviral vectors in human gene therapy.-Subject index