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High Throughput Screening: The Discovery of Bioactive Substances

Sprache: Englisch.
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Titel: High Throughput Screening: The Discovery of Bioactive Substances
Autor/en: John P. Devlin

ISBN: 0824700678
EAN: 9780824700676
Sprache: Englisch.
CRC PR INC

Mai 1997 - gebunden - 704 Seiten

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.
Natural Products as a Discovery Resource, edited by John P. Devlin Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin Microcollection of Plants for Biochemical Profiling, John P. Devlin Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman The Marine Environment as a Discovery Resource, Gregg R. Dietzman Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia Introduction, Michael R. Pavia Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dorner, John M. Ostresh, Colette Dooley, and Richard A. Houghten Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson Parallel Organic Synthesis Using Parke-Davis' Diversomer(R) Method, Sheila Hobbs DeWitt and Anthony W. Czarnik Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and Laszlo Kovacs Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder Assay Technologies and Detection Methods, edited by Alfred J. Kolb Introduction, Alfred J. Koin Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes FlashPlate(TM) Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon Ng Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. Wong A Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard Mathis Time-Resolved Fluorometry: Advantages and Potentials, Ilkka Hemmila Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. Manly Fluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert Bukar Reporter Gene Assay Applications, Winfried Scheirer Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De Grandis High-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana Williams Bioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rudiger Ridder Automation and Robotics, edited by Alfred J. Kolb Introduction, Alfred J. Kolb Management and Service Issues of a Centralized Robotic HTS Core, John Babiak Flexible Use of People and Machines, Mark Beggs and John S. Major Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. Bonhaus Factors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. Wood Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree Proulx Perspectives on Scheduling, Alain Donzel, Jorge Carmona, and L. Andrew Corkan Data Retrieval, Handling, and Integration, edited by John P. Devlin Introduction, John P. Devlin Database Systems, Barr E. Bauer Systems Integration, Chip Allee Data Management and Tracking for Natural Product Programs, Gregg R. Dietzman Laboratory Design and Management, edited by Matthew A. Sills Introduction, Matthew A. Sills Planning and Implementing an HTS Program, Matthew A. Sills and Mark Crawford Establishing an HTS Program in a Start-up Biotechnology Company, Michael D. Boisclair, James Schultz, and Dan Maloney
"a valuable reference. "-Journal of Pharmacy and Pharmacology "a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances. a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries. "-Journal of Medicinal Chemistry "an excellent compendiumcovering the breath of current HTS. It will serve as a standard text in the field. "-Journal of Natural Products This recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design. - European Journal of Pharmaceutics and Biopharmaceutics, 2000
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