Advances in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Inhaltsverzeichnis
1;Front Cover;1 2;ANNUAL REPORTS IN MEDICINAL CHEMISTRY, Volume 31;4 3;Copyright Page;5 4;CONTENTS;6 5;CONTRIBUTORS;10 6;PREFACE;12 7;SECTION I: CENTRAL NERVOUS SYSTEM DISEASES;14 7.1;Chapter 1. Neuropeptide Y: At the Dawn of Subtype Selective Antagonists;14 7.2;Chapter 2. Gonadal Steroid Receptors: Possible Roles in the Etiology and Therapy of Cognitive and Neurological Disorders;24 7.3;Chapter 3. P2 Purinoceptors: A Family of Novel Therapeutic Targets;34 7.4;Chapter 4. The Metabotropic Glutamate Receptors;44 7.5;Chapter 5. Drugs in Anesthetic Practice;54 8;SECTION II: CARDIOVASCULAR AND PULMONARY DISEASES;64 8.1;Chapter 6. Thrombin and Factor Xa Inhibition;64 8.2;Chapter 7. Inhibitors of Types I and V Phosphodiesterase: Elevation of cGMP as a Therapeutic Strategy;74 8.3;Chapter 8. Chronic Pulmonary Inflammation and Other Therapeutic Applications of PDE IV Inhibitors;84 8.4;Chapter 9. Endothelin Antagonists;94 8.5;Chapter 10. GPllb/llla Antagonists;104 8.6;Chapter 11. Atherothrombogenesis;114 8.7;Chapter 12. Neurokinin Receptor Antagonists;124 9;SECTION III: CANCER AND INFECTIOUS DISEASES;134 9.1;Chapter 13. Antibacterial Agents;134 9.2;Chapter 14. Semisynthetic Glycopeptide Antibiotics;144 9.3;Chapter 15. Chemotherapy of Malaria;154 9.4;Chapter 16. Recent Advances in Tyrosine Kinase Inhibitors;164 9.5;Chapter 17. Recent Advances in the Chemistry and Biology of Antimycobacterial Agents;174 9.6;Chapter 18. Ras Farnesyltransferase Inhibitors;184 10;SECTION IV: IMMUNOLOGY, ENDOCRINOLOGY, AND METABOLIC DISEASES;194 10.1;Chapter 19. Estrogen Receptor Modulators: Effects in Non-Traditional Target Tissues;194 10.2;Chapter 20. Cell Adhesion lntegrins as Pharmaceutical Targets;204 10.3;Chapter 21. Treating Obesity in the 21st Century;214 10.4;Chapter 22. Anti-Osteoporosis Agents;224 10.5;Chapter 23. Nitric Oxide Synthase Inhibitors;234 10.6;Chapter 24. Inhibition of Matrix Metalloproteinases;244 11;SECTION V: TOPICS IN BIOLOGY;254 11.1;Chapter 25. Cell Cycle Control and Can
cer;254 11.2;Chapter 26. Regulation of Apoptosis by Members of the ICE Family and the Bcl2 Family;262 11.3;Chapter 27. The Role of JAKs and STATs in Transcriptional Regulation by Cytokines;282 11.4;Chapter 28. Novel Inhibitors of the Proteasome and Their Therapeutic Use in Inflammation;292 11.5;Chapter 29. The MAP Kinase Family: New "MAPs" for Signal Transduction Pathways and Novel Targets for Drug Discovery;302 12;SECTION VI: TOPICS IN DRUG DESIGN AND DISCOVERY;312 12.1;Chapter 30. New NMR Methods for Structural Studies of Proteins to Aid in Drug Design;312 12.2;Chapter 31. Solid-Phase Synthesis: Applications to Combinatorial Libraries;322 12.3;Chapter 32. Application of Mass Spectrometry for Characterizing and Identifying Ligands from Combinatorial Libraries;332 12.4;Chapter 33. Plasma Protein Binding of Drugs;340 13;SECTION VII: TRENDS AND PERSPECTIVES;350 13.1;Chapter 34. To Market, To Market - 1995;350 13.2;Chapter 35. The Protein Structure Project, 1950-1959: First Concerted Effort of a Protein Structure Determination in the U.S.;370 14;COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOLUME 31;380 15;CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 131;386 16;CUMULATIVE NCE INTRODUCTION INDEX, 19831995;400 17;CUMULATIVE NCE INTRODUCTION INDEX, 19831995, BY INDICATION;412
