Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE, rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.
Inhaltsverzeichnis
Chemistry of Plasma Lipoproteins. - Heterogeneity of Apolipoprotein B Containing Lipoproteins. - Separation and Identification of Apo-B-Contining Lipoprotein Particles in Normolipidemic Subjects and Patients with Hyperlipoproteinemias. - HDL Subfractions, HDL Receptors and HDL Turnover. - Use of Monoclonal Antibodies to Human Apo A I in the Determination of Antigenic Sites Present on HDL Surface. - Epitope Expression in Purified and Lipoprotein Forms of Apolipoproteins A I and E. - Apolipoprotein D, Monoclonal Antibodies, and Cross-Reacting Proteins. - Characterization and Mode of Inheritance of Apolipoprotein E3-Leiden. - Results of the Study of Apoliprotein E and its Isomorphs on Isoelectric Focusing in Dyslipoproteinemias. - Ag System Re-Explored: Studies with Monoclonal Anti-Apoliprotein B Antibodies. - Use of Combined Monoclonal Antibodies for the Immunochemical Determination of Apolipoproteins A I and B in Human Plasma. - Metabolism of Plasma Lipoproteins. - Mechanism of Action of Lipoprotein Lipase and Hepatic Triglyceride Lipase. - The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolism. - Cholesteryl Ester Transfer in Atherosclerosis. - Metabolism of Apolipoprotein C: Kinetic Studies in Human Subjects: A Critical Review. - Turnover and Interconversion of LDL Sub-Fractions. - Metabolic Determinants of Plasma High-Density Lipoprotein Concentration in Humans. - Lipid Metabolism and the Enterohepatic Circulation: The Regulatory Functions of HMG CoA Reductase and Cholesterol 7? Hydroxylase. - The Role of the LDL Receptor in Lipoprotein Metabolism. - The Uptake of Chylomicron Remnants by the Liver. - The Receptor-Mediated Interaction of Lipoproteins with Liver Cells. - Disposal of HDL-Cholesterol to Cultured Granulosa Cells, Endothelial Cells and Hepatocytes: Effects of HDL-Phospholipolysis. - Diet and Drug Effects on Plasma Lipoproteins. - Effects of Dietary Fat Modifications on Plasma Lipids and Apolipoprotein Metabolism in Humans. - Effects of Diet Fat P/S Ratio on Serum Lipoprotein Concentrations. - Diet and HDL Metabolism: High Carbohydrate vs. High Fat Diets. - The Effects of Diet, Acute Exercise and Regular Training on Muscle Lipoprotein Lipase Activity. - Changes in Serum Lipoproteins and in Lecithin: Cholesterol Acyltransferase Activity with Dietary Fat Modification. - Cultured Fibroblast Interactions with LDL and HDL from Healthy Subjects on Various Dietary Fats. - Beta-Blocking Agents and Plasma Lipids: An Update. - Apolipoproteins Induced by an Antimitotic Agent. - Atherosclerosis and Coronary Heart Disease. - Meaning of a Modified LDL in Humans. - Latent Type IV. - HDL and Coronary Heart Disease; A Familial Trend. - Molecular Analysis of Lipoproteins: Clinical Applications. - Platelet Fibrinogen Binding in Familial Hypercholesterolemia. - Studies on the Correlation Between the Quantity of LDL-Binding Sites of Platelets and the Serum Cholesterol Levels. - Contributors.
