Proceedings of an international conference held in Magdeburg, Germany, November 3-5, 1996
Inhaltsverzeichnis
I: Membrane Peptidases in Immune Functions and Inflammation. - 1. Membrane Metalloendopeptidases in Immune Function and Disease. - 2. Structural Studies of Aminopeptidase P: A Novel Cellular Peptidase. - 3. Aminopeptidase P: A Cell-Surface Antigen of Endothelial and Lymphoid Cells. - 4. Human Lymphocyte X-Prolyl Aminopeptidase (Aminopeptidase P)-like Protein: A New Member of the Proline Peptidase Family? . - 5. Specific Inhibitors of Aminopeptidase P: Peptides and Pseudopeptides of 2-Hydroxy-3-Amino Acids. - 6. ? -Glutamyl Transpeptidase, a Blood-Brain Barrier Associated Membrane Protein: Splitting Peptides to Transport Amino Acids. - 7. Structure and Expression of Aminopeptidase N. - 8. Activation-Dependent Induction of T Cell Alanyl Aminopeptidase and Its Possible Involvement in T Cell Growth. - 9. Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells. - 10. Co-Incubation of Lymphocytes with Fibroblast-like Synoviocytes and Other Cell Types Can Induce Lymphocytic Surface Expression of Aminopeptidase N/CD13. - 11. Two Transfected Endothelial Cell Lines Expressing High Levels of Membrane Bound or Soluble Aminopeptidase N. - 12. Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells. - 13. Regulation of Thymic Development by Neprilysin Inhibition. - 14. Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation. - II: CD26/Dipeptidylpeptidase IV on Lymphocytes. - 15. Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation. - 16. Molecular Associations Required for Signalling via Dipeptidyl Peptidase IV (CD26). - 17. CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation. - 18. CD26 Is Involved in Regulation of CytokineProduction in Natural Killer Cells. - 19. The Effect of Anti-CD26 Antibodies on DNA Synthesis and Cytokine Production (IL-2, IL-10 and IFN-?) Depends on Enzymatic Activity of DP IV/CD26. - 20. New Fluorogenic Dipeptidyl Peptidase IV/CD26 Substrates and Inhibitors. - 21. Molecular Analyses of Human and Rat Dipeptidyl Peptidase IV. - 22. A Molecular Model of the Active Site of Dipeptidyl Peptidase IV: Explanation of the Substrate Specificity and Interaction with Inhibitors. - 23. The Level of CD26 Determines the Rate of HIV Entry in a CD4+ T-Cell Line. - 24. HIV-1 Envelope gp 120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26. - 25. Further Characterization of DPP IV-? , a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity. - 26. Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity. - 27. CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4+ T Cells. - 28. Comparative Study of CD26 as a Thl-like and CD30 as a Potential Th2-like Operational Marker in Leprosy. - III: Peptidases Involved in Cytokine Actions and in the Pathogenesis of Disease. - 29. Regulation of Neutrophil Activation by Proteolytic Processing of Platelet-Derived a-Chemokines. - 30. Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases. - 31. In Vitro Effects of ? -Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells. - 32. Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells. - 33. Lysosomal Cysteine Peptidases and Malignant Tumours. - 34. Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin Cin Human Lung Tumor Tissue. - 35. Contribution of the Proteasome to the a-Secretase Pathway in Alzheimer s Disease. - 36. Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositìs. - 37, The HIV Protease and Therapies for AIDS. - 38. Leukodiapedesis, Function, and Physiological Role of Leucocyte Matrix Metalloproteinases. - 39. Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis. - 40. Interaction of Transforming Growth Factor ß (TGFß) with Proteinase 3. - 41. Liver Cysteine Proteinases in Macrophage Depression Induced by Gadolinium Chloride. - Contributors.
