Ubiquitin Proteasome System in CNS Neurodegenerative Diseases

This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems.

The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.

Section I: Introduction to Ubiquitin Proteasome System (UPS). - Chapter 1: Ubiquitin Proteasome System (UPS): Role in Cellular Physiology. - Chapter 2: Ubiquitin Proteasome System (UPS) and Molecular Chaperones. - Chapter 3: Ubiquitin Proteasome System (UPS) and Energy Bioenergetics. - Section II: Signaling Mechanisms in Ubiquitin Proteasome System (UPS). - Chapter 4: Protein Homeostasis and Ubiquitin Proteasome System (UPS). - Chapter 5: Neuroinflammation and Ubiquitin Proteasome System (UPS). - Chapter 6: Endoplasmic Reticulum and Ubiquitin Proteasome System (UPS). - Chapter 7: Triggers of Ubiquitin Proteasome System (UPS): Disease Aspects. - Chapter 8: Ubiquitin Signaling in Central Nervous System (CNS) Neurodegenerative Diseases. - Chapter 9: E3 Ubiquitin Ligases in Central Nervous System (CNS) Neurodegenerative Diseases. - Chapter 10: Deubiquitinating Enzymes in Central Nervous System (CNS) Neurodegenerative Disease. - Chapter 11: Proteasome Machinery in Neurodegenerative Signaling. - Section III: Therapeutic Options for Ubiquitin Proteasome System (UPS). - Chapter 12: Targeting Ubiquitin Proteasome System (UPS) by Natural Products. - Chapter 13: Inhibitors of Protein Aggregates. - Chapter 14: HDAC Inhibitors on Protein Quality Control System. - Section IV: Experimental Tools for Ubiquitin Proteasome System (UPS). - Chapter 15: Animal Models of Disease. - Chapter 16: Pros and Cons of Sporadic Versus Genetic Models of Diseases.