Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.

1;Front Cover;1 2;Annual Reports in Medicinal Chemistry, Volume 33;4 3;Copyright Page;5 4;Contents;6 5;CONTRIBUTORS;12 6;PREFACE;14 7;SECTION 1: CENTRAL NERVOUS SYSTEM AGENTS;16 7.1;Chapter 1. Dopaminerglc Approaches to Antipsychotic Agents;16 7.2;Chapter 2. Novel Molecular Approaches to Analgesia;26 7.3;Chapter 3. Latest Developments in Serotonin Receptor Modulation;36 7.4;Chapter 4. Recent Advances in Histamine H3 Receptor Agents;46 7.5;Chapter 5. Galanin Receptors: Recent Developments and Potential Use as Therapeutic Targets ;56 7.6;Chapter 6. Sodium Channels: Recent Developments and Therapeutic Potential;66 7.7;Chapter 7. Recent Progress in Antiepileptic Drug Research;76 8;SECTION II: CARDIOVASCULAR AND PULMONARY DISEASES;86 8.1;Chapter 8. Recent Advances in Neurokinin Receptor Antagonists;86 8.2;Chapter 9. Thrombosis and Coagulation;96 8.3;Chapter 10. Phosphodiesterases 4 Inhibitors;106 8.4;Chapter 11. Adenosine;126 9;SECTION III: CANCER AND INFECTIOUS DISEASES;136 9.1;Chapter 12. Antimicrobial Potentiation Approaches: Targets and Inhibitors;136 9.2;Chapter 13. Matrix Metalloproteinase Inhibitors and Cancer;146 9.3;Chapter 14. Recent Developments in Antibacterial Research;156 9.4;Chapter 15. Recent Developments in Cancer Cytotoxics;166 9.5;Chapter 16. Advances in Nucleoside and Nucleotide Antiviral Therapies;178 9.6;Chapter 17. Non-Azole Antifungal Agents;188 10;SECTION IV: IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC DISEASES;198 10.1;Chapter 18. Blocking Interleukin-1 Action;198 10.2;Chapter 19. ß3 Adrenergic Receptor Agonists for the Treatment of Obesity;208 10.3;Chapter 20. New Treatments for Arthritis;218 10.4;Chapter 21. Recent Advances in the Development of Agents for the Treatment of Type 2 Diabetes ;228 10.5;Chapter 22. Prostanoid Receptors;238 11;SECTION V: TOPICS IN BIOLOGY;248 11.1;Chapter 23. Kinases in Pro-inflammatory Signal Transduction Pathways: New Opportunities for Drug Discovery ;248 11.2;Chapter 24. Macrophage Migration Inhibitory Factor (MIF):
A Critical Upstream Regulator of Acute and Chronic Inflammatory Responses ;258 11.3;Chapter 25. The Bcl-2 Family: Targets for the Regulation of Apoptosis;268 11.4;Chapter 26. Chemokine Receptors as HIV Co-Receptors: Targets for Therapeutic Intervention in AIDS ;278 11.5;Chapter 27. Roles of Caspases in Inflammation and Apoptosis: Prospects as Drug Discovery Targets ;288 12;SECTION VI: TOPICS IN DRUG DESIGN AND DISCOVERY;298 12.1;Chapter 28. Predictive Toxicology: An Overview;298 12.2;Chapter 29. The Use of Surface Plasmon Resonance Based Biosensors in Drug Discovery ;308 12.3;Chapter 30. Current and Future Trends in High Throughput Screening for Drug Discovery ;316 12.4;Chapter 31. Second Generation Antisense Oligonucleotides: 2-Modifications;328 13;SECTION VII: TRENDS AND PERSPECTIVES;342 13.1;Chapter 32. To Market, To Market - 1997;342 13.2;Chapter 33. Gender Based Medicine;370 13.3;Chapter 34. Technology Providers and Integrators - A Virtual Architecture for Drug R & D? ;380 13.4;Chapter 35. Chemoinformatics: What is it and How does it Impact Drug Discovery;390 13.5;Chapter 36. Glossary of Terms Used in Medicinal Chemistry (IUPAC Recommendations 1997) ;400 13.6;Chapter 37. Glossary of Terms Used in Computational Drug Design (IUPAC Recommendations 1997);412 14;COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOLUME 33;426 15;CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 1-33;434 16;CUMULATIVE NCE INTRODUCTION INDEX, 1983-1 997;450 17;CUMULATIVE NCE INTRODUCTION INDEX, 1983-1997, BY INDICATION;464