Rubella Viruses

This latest volume provides a comprehensive review of the latest developments and research studies on the pathogenesis and molecular biology of human congenital infections. It reviews current diagnostic techniques and epidemiological data while describing the progress in research and understanding of continuing prevention of congenital infections and prognosis.

1;Cover;1 2;Copyright page;5 3;Contents;6 4;Preface;8 5;Historical Introduction;10 6;Chapter 1. Molecular Virology of Rubella Virus;14 6.1;Introduction;14 6.2;Structure of the virion;15 6.3;Genome organization;18 6.4;Attachment and entry;18 6.5;Intracellular site of RNA replication;20 6.6;Transcription and translation;20 6.7;Genome replication;21 6.8;Interactions between rubella virus proteins and cellular proteins involved in cell cycle regulation;23 6.9;Assembly of virions;24 6.10;Molecular epidemiology of rubella;25 6.11;General comments about the molecular virology of rubella virus;27 6.12;References;27 7;Chapter 2. Clinical Features: Post-Natally Acquired Rubella;32 7.1;Introduction;32 7.2;Clinical features;32 7.3;Differential diagnosis;34 7.4;Complications;34 7.5;Congenitally acquired infection;36 7.6;References;47 8;Chapter 3. Laboratory Diagnosis of Rubella and Congenital Rubella;52 8.1;Introduction;52 8.2;Laboratory techniques;53 8.3;Diagnosis of rubella;67 8.4;Remaining diagnostic problems;81 8.5;Conclusions and outlook;82 8.6;Acknowledgements;83 8.7;References;83 9;Chapter 4. Rubella Vaccine;92 9.1;Introduction;92 9.2;Active immunization;92 9.3;Dose and route of administration;94 9.4;Combination of the vaccine;94 9.5;Immune responses;95 9.6;Protective effects and reinfection;96 9.7;Adverse events;97 9.8;Contraindications and precautions;99 9.9;Use of rubella-containing vaccine globally;100 9.10;Cost-effectiveness of rubella-containing vaccines in developing countries;102 9.11;Summary;102 9.12;References;103 10;Chapter 5. Rubella Epidemiology: Surveillance to Monitor and Evaluate Congenital Rubella Prevention Strategies;108 10.1;Congenital rubella infection;108 10.2;Epidemiological features of the rubella virus;111 10.3;Prevention of congenital rubella;113 10.4;References;123 11;Future Requirements;128 12;List of Contributors;130 13;Index;132