Pharmaceutical process research and development is an exacting, multidisciplinary effort but a neglected discipline in the chemical curriculum. This book presents an overview of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. The concise chapters cover such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation and ends with an assessment of future trends and challenges.
Inhaltsverzeichnis
Foreword; Preface; Introduction; Process Research and Development in the Pharmaceutical Industry: Origins, Evolution and Progress; Active Pharmaceutical Ingredients: Structure and Impact on Synthesis; Rapid Early Development of Potential Drug Candidates; Route Design and Selection The Importance of Green Chemistry in Process Research and Development; Kinetic Approaches for Faster and Efficient Process Development; The Design of Safe Chemical Reactions - It's No Accident; Physicochemical Data Requirements for the Design of Fine Chemical Processes - Acquisition and Application; Liquid-Liquid Extraction for Process Development in the Pharmaceutical Industry; Development Enabling Technologies; The Analytical Interface and the Impact on Pharmaceutical Process Development; Materials Science - Solid Form Design and Crystallisation Process Development; Technology Transfer of API; Future Trends and Challenges;
