This book provides a comprehensive guide to state-of-the-art knowledge, techniques and tools in the transporter sciences relating to drug metabolism and pharmacokinetics. There are currently no books that can be referred to by students and industrial scientists alike for clear, detailed information on relevant drug transporter science. Regulatory authorities and pharmaceutical companies have recognized the need to understand and quantify the effects of drug transporters within the human body. Case studies and information on emerging areas will be included throughout the book. The book will be relevant to those working in drug discovery and development and can be cross promoted with other titles in the RSC Drug Discovery Series. It could also be cross-promoted with the Biomolecular Series Books and the jounal MedChemComm.
Inhaltsverzeichnis
Overview of drug transporter families and their role in drug development; Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions; Intestinal transporters; Kidney transporters; CNS transporters; Lung transporters; The use of in vitro and in silico systems for investigating transporter interactions; The use of transgenic and knockout in vivo systems for investigating transporter interactions; Modelling and simulation of transporter interactions; Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective; Regulatory requirements, Labelling and Drug Transporters; Recent Advances and Emerging Technologies; Bioinformatics; Regulation of transporters; Transporter Pharmacogenomics; Transporter Imaging; Transporters and Proteomics
