Genetics Meets Metabolomics

Written by leading researchers, this book explores the intersection of genetics and metabolomics, and points the way to more comprehensive studies of inborn variation of metabolism. All chapters refer to one or more published experimental datasets.

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Introduction. - Pre-conditions for high quality biobanking in large human epidemiological cohorts for metabolomics and other -omics studies. - Assay Tools for Metabolomics. - Statistical methods in genetic and molecular epidemiology and their application in studies with metabolic phenotypes. - Ultrahigh resolution mass spectrometry based non-targeted microbial metabolomics. - etabolomic systems biology of protozoan parasites. - Mouse genetics and metabolic mouse phenotyping. - Metabolomics in animal breeding. - Metabolomics applications in human nutrition. - Metabolomics for the individualized therapy of androgen deficiency syndrome in male adults. - Systems biology resources arising from the human metabolome project. - Understanding cancer metabolism through global metabolomics. - Genetic and metabolic determinants of fatty acid chain length and desaturation, their incorporation into lipid classes and their effects on risk of vascular and metabolic disease. - Mapping metabolomic quantitative trait loci (mQTL) A link between metabolome-wide association studies and systems biology. - Metabolic traits as intermediate phenotype. - Genome-wide association studies with metabolomics. - Systems biology meets metabolism. - Index.