It would be difficult to think of a more important field of study in medicine than the interaction of cells with natural and foreign surfaces, but it is rare for those in the practice of medicine and surgery to get together with the basic scientists to discuss what they know about it, so that ground of common interest can be explored. Perhaps the symposium should have been entitled "Interactions between those interested in cell surfaces --- " because it is here that the chief value of such meetings must lie. Even a brief perusal of this volume shows just how far advanced thought and work are on some facets of the topic. Some of the most pressing problems in medicine are those of tumour spread and of thrombosis of blood vessels where surface phenomena are of paramount importance. Our understanding is still very limited but, as the symposium illustrated, the answers are only to be found by study at fundamental levels, the work gaining direction and point from interaction with surgeons and others concerned with the actual disease states.
Inhaltsverzeichnis
Section 1 Cell Surface Membranes: Molecular and Electrokinetic Properties. - Structural organisation and function of cell surface membranes. - Electrokinetic aspects of cell surfaces. - Fibronectin: Role in cell surface interactions. - Cytoskeletal and cytocontractile features of myofibroblasts. - Section 2 Cell Surface Interactions and Biotolerance: Basic Aspects. - Endothelium as a haemocompatible surface. - Interaction of blood, blood components and surfaces. - Cellular aspects of biotolerance. - Surface property requirements for biomaterials. - Surface emission and biological probes for inorganic interfaces. - Section 3 Cellular Interactions in Vascular Grafts and Extracorporeal Circuitry. - Cellular interactions in extracorporeal circuitry. - Interactions of white cells and the humoral cascades during cardiopulmonary bypass in man. - Assessment of platelet inhibitory therapy for arterial prostheses in an invivo canine model. - Evolution of the subendothelial growth on heparinised aldehyde crosslinked arteries. - The influence of thromboxane receptor blockade on platelet uptake in dacron grafts in man. - Plasma fibronectin and platelet deficiency following aortic cross-clamping. - Section 4 Cell Surface Interactions and Tumour Metastases. - Cell surface alterations and the metastatic behavior of tumor cells. - Interaction of platelets, tumor cells and subendothelial surfaces. - Fibrinolysis and its effect on tumour growth and metastasis. - Pericellular proteoglycans and metastasis formations Modulation by hydrocortisone and growth factors. - Section 5 Cellular Interactions: Granulomas, Healing Wounds, Dressings and Sutures. - The mononuclear phagocyte system in granulomas. - The role of collagen in healing wounds. - The rabbit ear chamber: A study of cell interactions. - The treatment of skingraft donor sites. - The effect of surgical dressings on skin temperature. - Cellular responses to sutures. - Section 6 Other Clinical Aspects of Biocompatibility. - An experimental study of calculogenesis and biocompatibility of plastics for urological use. - The mechanical and biological properties of filamentous carbon or polypropylene mesh in the rat abdominal wall. - The possible role of implant materials in promoting the aseptic loosening of prosthetic joints. - Evaluation of the histologic response to a polyacrylamide-agar hydrogel in the rat. - Cellular interactions with dental materials. - CELL-SURFACE INTERACTIONS Summary and Concluding Remarks. - Contributors.
