Macro-Glycoligands

This volume details methods and protocols for the synthesis and characterization of glycopolymers and their biomedical applications. Chapters are divided into three parts covering synthesis and characterization of glycopolymers; glycopolymer-nanoparticle conjugates; and surface immobilized glycopolymers. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Macro-Glycoligands: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Synthesis of Chain-end Functionalized Glycopolymers
via
Cyanoxyl Mediated Free Radical Polymerization (CMFRP). - Protecting-group-free Synthesis of Well-defined Glycopolymers Featuring Negatively Charged Oligosaccharides. - Glycopolymers Prepared by Ring-opening Metathesis Polymerization Followed by Glycoconjugation Using a Triazole Forming `Click Reaction. - Protecting-group-free Synthesis of Glycopolymers and Their Binding Assay with Lectin and Influenza Virus. - Carbohydrate-based Initiators for the Cationic Ring-opening Polymerization of 2-Ethyl-2-oxazoline. - Heterofunctional Glycopolypeptides by Combination of Thiol-ene Chemistry and NCA Polymerization. - Preparation of Proteoglycan Mimetic Graft Copolymers. - Galactosylated Polymer Nano-objects by Polymerization-Induced Self-Assembly, Potential Drug Nanocarriers. - Synthetic Approach to Biotinylated Glyco-Functionalized Quantum Dots: A New Fluorescent Probes for Biomedical Applications. - Surface Modification of Polydivinylbenzene Microspheres with a Fluorinated Glycopolymer using Thiol-Halogen Click Chemistry. - Glycopolymer-grafted Polymer Particles for Lectin Recognition. - Synthesis of Non-spherical Glycopolymer-decorated Nanoparticles: Combing Thiol-ene with Catecholic Chemistry. - Synthetic Approach To Glycopolymer Base Nanoparticle Gold(I) Conjugate: A New Generation Of Therapeutic Agents. - Multivalent Glycopolymer-coated Gold Nanoparticles. - Modulation of Multivalent Protein Binding on Surfaces by Glycopolymer Brush Chemistry. - Oriented ImmobilizedSialyloligo-Macroligand Microarray. - Glycocalyx Remodeling with Glycopolymer-based Proteoglycan Mimetics.