Histopathology of Nodal and Extranodal Non-Hodgkin's Lymphomas

The Kiel classification of Non-Hodgkin lymphomas is an important tool for every histopathology laboratory! It leads to very exact differential diagnosis by distinguishing the various disease types from each other. In this updated second edition, the clear differentiation of T-cell lymphomas particularly stands out, as do the increased number of illustrations. The section dealing with immunohistochemistry has been completely rewritten by A.C. Feller. He compares the findings of monoclonal antibody investigations with the morphology. The clinical data and contribution on therapy build a bridge to the clinical treatment of malignant lymphoma. Yet throughout, the histological diagnosis and differential diagnosis remain the central focus of the book.

During the 10 years since the last edition of Histopathology of Non-Hodgkin' s Lymphomas, based on the updated Kiel classification, our knowledge on malignant lymphomas, especially on extranodal lymphomas, has increased. This volume - Histopathology of Nodal and Extranodal Non-Hodgkin' s Lymphomas - is an expanded and completely revised edition, now based on the WHO classification. The parallels to the updated Kiel classification and the REAL classification are indicated. The information is organized in organ-specific chapters, comprising the well-known nodal lymphoma entities as well as all known extranodal lymphomas and the different organ-specific clinico-pathological entities: lymphomas of the spleen, the gastrointestinal tract, the skin, etc. In addition to the morphology, the major immunohistochemical, molecular genetic, and clinical data are included in each chapter.

1 History of Lymphoma Classification. - 1. 1 Introduction. - 1. 2 The Kiel Classification. - 1. 3 The REAL Classification Proposal. - 1. 4 The WHO Classification. - References. - 2 Current Status of Lymphoma Classification. - 2. 1 Introduction. - 2. 2 Small- and Large-Cell Versus Low- and High-Grade. - 2. 3 Primary Versus Secondary Lymphoma. - 2. 4 Definition of Immunocytoma and Its Border with Marginal Zone B-Cell Lymphoma. - 2. 5 Indistinct Border Between Nodal Marginal Zone B-Cell Lymphoma and Follicular Lymphoma with Marginal Zone Differentiation. - 2. 6 Grading of Follicular Lymphoma. - 2. 7 Distinction Between Diffuse Large B-Cell Lymphoma and Burkit s Lymphoma: Reproducibility and Value of Subclassification. - 2. 8 Problems in Reproducibly Recognizing Anaplastic Large-Cell Lymphoma and Lymphoblastic Lymphoma on Purely Morphological Grounds. - 2. 9 Is Peripheral T-Cell Lymphoma, Unspecified a Distinct Clinicopathological Entity or a Catchall Term? . - 2. 10 Neither the WHO nor the EORTC Classification of Cutaneous Lymphoma Covers Today s Knowledge. - References. - 3 Epidemiology. - 3. 1 Introduction. - 3. 2 Statistical Data of the Kiel Lymphoma Registry. - References. - 4 Nodal B-Cell Lymphoma. - 4. 1 Precursor B-Cell Lymphoblastic Leukemia. - 4. 2 Peripheral B-Cell Lymphoma. - References. - 5 Nodal and Leukemic NK/T-Cell Lymphoma. - 5. 1 Precursor T-Lymphoblastic Leukemia/Lymphoma. - 5. 2 Peripheral NK/T-Cell Lymphoma. - References. - 6 Extranodal Lymphoma. - 6. 1 Introduction. - 6. 2 Gastrointestinal Lymphoma. - 6. 3 Lymphoma of the Upper Aerodigestive Tract. - 6. 4 Malignant Lymphoma of the Major Salivary Glands. - 6. 5 Lymphoma of the Eye, Lachrymal Glands, and Orbit. - 6. 6 Lymphoma of the Mediastinum. - 6. 7 Lymphoma of the Lung. - 6. 8 Lymphoma of the Pleura. - 6. 9 Lymphoma of the Heart. - 6. 10 Splenic Lymphoma. - 6. 11Lymphoma of the Liver. - 6. 12 Lymphoma of the Breast, Reproductive, and Urinary Systems. - 6. 13 Endocrine Gland Lymphoma. - 6. 14 Cutaneous Lymphoma. - 6. 15 Lymphoma of Soft Tissues. - 6. 16 Lymphoma of the Bone. - 6. 17 Lymphoma of the Central Nervous System. - 6. 18 Intravascular Large-B-Cell Malignant Lymphoma. - References. - 7 Plasma Cell Proliferations. - 7. 1 Plasma Cell Myeloma/Bone Marrow Plasmacytoma. - 7. 2 Extraosseous (Extramedullary) Plasmacytoma. - 7. 3 Associated Diseases. - 7. 4 Heavy-Chain Diseases. - References. - 8 Lymphoma Occurring in a Setting of Immunodeficiency. - 8. 1 Lymphoproliferative Disorders Associated with Congenital Immunodeficiencies. - 8. 2 Lymphoma and Lymphoproliferative Disorders Associated with Acquired Immunodeficiency. - References. - 9 Practical Guidelines for Lymphoma Diagnosis in Bone Marrow. - 9. 1 Patterns of Involvement. - 9. 2 Associated Lesions or Modifications. - 9. 3 Diagnosis of Bone Marrow Involvement According to the Different Types of Lymphoma. - 9. 4 Differential Diagnosis. - References. - 10 Practical Advice: Methods for the Diagnosis of Malignant Lymphoma. - 10. 1 The Diagnosis of Malignant Lymphoma. - 10. 2 Immunohistochemistry and Molecular Clonality Analysis in the Diagnosis of Lymphoma. - References.