Physics at the Biomolecular Interface

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics.

Chapter 1 Interfacial Physics for Water in Biology. - Chapter 2 Dielectric Structure of Aqueous Interfaces: From Classical non-Debye Electrostatics to a Quantum Theory of Interfacial Tension. - Chapter 3 Solution to the Protein Folding Problem. - Chapter 4 Epistructural Dynamics of Biological Water. - Chapter 5 Dehydron-Rich Proteins in the Order-Disorder Twilight Zone. - Chapter 6 Dehydron as a Marker for Molecular Evolution: Lessons for the Drug Designer. - Chapter 7 Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water. - Chapter 8 Epistructural Selectivity Filters for Molecular Targeted Therapy. - Chapter 9 Epistructural Re-Engineering ofImatinib to Eliminate Adverse Side Effects. - Chapter 10 Epistructural Informatics for the Drug Designer. - Chapter 11 Drug-Target Associations Inducing Protein Folding. - Chapter 12 Combination Therapies to Edit Out Side Effects and Resistance to Inhibition of Drug Resistance. - Chapter 13 Epistructure-Based Design of Drugs with Controlled Promiscuity. - Chapter 14 Synergizing Engineered Immunotherapy with Molecularly Targeted Cancer Treatment. - Chapter 15 Quantum Mechanical Concepts for Epistructural Drug Design. - Chapter 16 Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations. - Chapter 17 Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug Resistance.