Inhaltsverzeichnis
I: Functions of stress proteins in unstressed cells. - Normal protein folding machinery. - Roles for hsp70 in protein translocation across membranes of organelles. - Protein folding and assembly in the endoplasmic reticulum. - Involvement of molecular chaperones in intracellular protein breakdown. - Molecular chaperoning of steroid hormone receptors. - Protein disulfide isomerase: A multifunctional protein of the endoplasmic reticulum. - II: Regulation of inducible stress responses. - Sensing stress and responding to stress. - The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions. - Transcriptional regulation of stress-inducible genes in procaryotes. - The impact of oxidative stress on eukaryotic iron metabolism. - Heat-shock induced protein modifications and modulation of enzyme activities. - SOS response as an adaptive response to DNA damage in prokaryotes. - III: Cellular responses to specific stresses. - Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes. - UV activation of mammalian stress proteins. - Signaling events controlling the molecular response to genotoxic stress. - Mammalian DNA repair responses and genomic instability. - Toxic metal-responsive gene transcription. - Tumor necrosis factor and lymphotoxin: Protection against oxidative stress through induction of MnSOD. - IV: Paradigms for complex stress responses. - Viral infection. - Infection, autoimmunity and autoimmune disease. - Stress proteins in inflammation. - Attenuated heat shock transcriptional response in aging: Molecular mechanism and implication in the biology of aging. - V: Applications of stress responses in toxicology and pharmacology. - Stress proteins as molecular biomarkers for environmental toxicology. - Thermotolerance and heat shock proteins: Possible involvement of Ku autoantigen in regulating HSP70 expression. - Heat shock proteins as immunological carriers and vaccines. - Regulation of thermotolerance and ischemic tolerance. - Future applications. - Outlook.
