This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Inhaltsverzeichnis
Preface. - Part I. - Evolution of voltage-gated sodium channels. - 1. Evolutionary History of Voltage-Gated Sodium Channels. - 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function. - 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective. - 4. The Cardiac Sodium Channel and Its Protein Partners. - 5. : Posttranslational Modification of Sodium Channels. - 6. Sodium Channel Trafficking. - 7. pH Modulation of Voltage-Gated Sodium Channels. - 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C. - Part III. Drugs and toxins interactions with sodium channels. - 9. Toxins That Affect Voltage-Gated Sodium Channels. - 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels. - 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels. - 12. Structural Models of Ligand-Bound Sodium Channels. - 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1. 7. - Part IV. Pathophysiology of sodium channels. - 14. Sodium Channelopathies of Skeletal Muscle. - 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction. - 16. Translational Model Systems for ComplexSodium Channel Pathophysiology in Pain. - 17. Gating Pore Currents in Sodium Channels. - 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells. - 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases.
