Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin peptides, Melanocortin-1-Receptors through Melanocortin-5-Receptors. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, and other clinical and experimental investigators working in this fast moving field.
Inhaltsverzeichnis
I. Historical Perspectives. - 1 Proopiomelanocortin and the Melanocortin Peptides. - 2 Melanocortins and Pigmentation. - 3 Melanocortins and Adrenocortical Function. - 4 Effects of Melanocortins in the Nervous System. - 5 Peripheral Effects of Melanocortins. - II. Characterization of the Melanocortin Receptors. - 6 Melanocortin Receptor Expression and Function in the Nervous System. - 7 Cloning of the Melanocortin Receptors. - III. Biochemical Mechanism of Receptor Action. - 8 The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure Activity Relationships for Melanotropins at Melanocortin Receptors. - 9 In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding. - IV. Receptor Function. - 10 The Melanocortin-1 Receptor. - 11 The Human Melanocortin-1 Receptor. - 12 The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance. - 13 The Melanocortin-3 Receptor. - 14 The Melanocortin-4 Receptor. - 15 The Melanocortin-5 Receptor. - V. Receptor Regulation. - 16 Regulation of the Melanocortin Receptors by Agouti. - 17 Melanocortins and Melanoma. - 18 Regulation of the Mouse and Human Melanocortin-1 Receptor. - VI. Future Vistas. - 19 Future Vistas.
