Lupus

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

1 Lupus: The Clinical Entity. - 2 The Vascular Endothelium: A New Actor in The Pathogenesis of Vascular Injury in Systemic Lupus Erythematosus. - 3 Nitric Oxide in Systemic Lupus Erythematosus: Implications for Immunity and Inflammation. - 4 Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus. - 5 Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells: Implications for Pathogenesis of SLE. - 6 Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus. - 7 Genetics of Systemic Lupus Erythematosus. - 8 Genetic Insights into Murine Lupus. - 9 Murine Graft-vs-Host Disease: Relevance to Human Lupus Immunopathogenesis and Therapy. - 10 Lessons From Knockout and Transgenic Lupus-Prone Mice. - 11 B Cells in Systemic Lupus Erythematosus. - 12 Mechanisms of the Pathogenic Autoimmune Response in Lupus: From Mouse Models to Human Disease. - 13 T-Cell Autoimmunity in Lupus: Ignorance, Anergy, and Activation. - 14 T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosis Models. - 15 Mechanisms of T Helper Cell Activation and Function in Systemic Lupus Erythematosus. - 16 A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes. - 17 Impaired DNA Methylation in Lupus T Cells. - 18 Impaired Non Antigen-Specific T-Cell Cytolytic Activity in SLE. - 19 Natural Killer Cells and CD8+ T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE: A Role for Transforming Growth Factor-? and Interleukin-2. - 20 Cytokines in the Immunopathogenesis of Lupus. . - 21 Cytokine Gene Expression in Human Systemic Lupus Erythematosus. - 22 Balance Between Type 1 and Type 2Cytokine-Secreting Cells: Impact on Disease Activity in Systemic Lupus Erythematosus. - 23 Autoantibodies as a Source of Peptides That Regulate Autoantibody Production. - 24 Autoantibodies to Intracellular Antigens in Systemic Lupus Erythematosus Patients That Bind and Penetrate Cells. - 25 Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice: An Inducible Model of SLE. - 26 Anti-DNA Antibodies: Markers of the Pathogenesis of Systemic Lupus Erythematosus. - 27 The Anti-DNA Response in Lupus: Structure, Initiation, and Pathogenesis. - 28 Glomerular Binding Antibodies in Systemic Lupus Erythematosus. - 29 The Antiphospholipid Syndrome: Mechanisms of Autoantibody-Mediated Thrombosis. - 30 Autoimmune-Associated Congenital Heart Block: Bringing Bedside Challenges to the Bench. - 31 Role of Calreticulin Autoimmunity in the Pathogenesis of Photosensitive Cutaneous Lupus Erythematosus. - 32 Complement System and Systemic Lupus Erythematosus. - 33 Type One Complement Receptor and Human SLE. - 34 Fc? Receptor Polymorphisms: Insights into Pathogenesis. - 35 Immune Complexes and Autoantibodies to C1q. - 36 Lipids and Lupus: The Fats of the Matter. - 37 Immunosuppressive Agents: Biologic Effects In Vivo and In Vitro. - 38 Treatment of Systemic Lupus Erythematosus by Selective Inhibition of T-Cell Function. - 39 Targeting Costimulatory and Other Signaling Molecules in Murine Lupus. - 40 Management of Murine Lupus by Correction of Fas and Fas Ligand Induced Apoptosis: Therapeutic Rationale and Strategies.