Bioinformatics and Biomedical Engineering

This two-volume set LNBI 16050-16051 constitutes the proceedings of the 12th International Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2025, held in Canaria, Spain, during July 16-18, 2025.

The 57 full papers presented in these volumes were carefully reviewed and selected from 98 submissions. They were organized into the following topical sections:

Part I: Advances in Deep Learning in Bioinformatics and Bioengineering; Bioinformatics and Biomedical Applications; Biomarker Identification; Biomedical Computing; and Biomedical Engineering.

Part II: Biosensors and Data Acquisition; Emerging Trends and Innovations in E-Health; High Performance in Bioinformatics; Innovations in Cancer Research: The Role of Bioinformatics and Biomedical Engineering; Machine Learning in Bioinformatics and Biomedicine; and Recent Advances in Bioinformatics.

. -
Biosensors and Data Acquisition
.

. - Methods for Wearable Electrocardiogram and Photoplethysmogram Synchronization.

. - Optimization of the Tau Parameter in Phase Space Plots for ECG Signal Quality Assessment.

. - Use of the graphic tablet for monitoring and analysis of the spatial and temporal characteristics of a precise manual task.

. -
Emerging Trends and Innovations in E-Health
.

. - Vision Language Models for Dynamic Human Activity Recognition in Healthcare Settings.

. - Method for detection and analysis of the sit-to-walk transition in older adults. Threshold-based transition detection application: a case study.

. - Agent-Based Modeling of Retinal Development.

. -
High Performance in Bioinformatics
.

. - Benchmarking variant calling algorithms for the analysis of genomic data in panel sequencing.

. - VCFX: A Minimalist, Modular Toolkit for Streamlined Variant Analysis.

. - Machine Learning-Based Screening Tool for Lung Adenocarcinoma Via Gut Microbiome.

. - Cost-Effective Microbiome Profiling: Abridged Shotgun Sequencing.

. - Correlation between CYP1A2 Genetic Polymorphism and Drug ResponseI.

. - A Systematic Comparison of Phylogenetic Inference Methods Using an Inverse Problem Approach.

. -
Innovations in Cancer Research: The Role of Bioinformatics and Biomedical Engineering
.

. - Differential Flux-balance Analysis infers metabolic mutations associated with cancer.

. - Explainable AI for Clinical Decision-Making: Unlocking the Potential of MSI Thresholds in Bladder Cancer.

. - IGHV Mutational Status and DNA Entropy: Refining Prognostic Tools in Chronic Lymphocytic Leukemia.

. -
Machine learning in Bioinformatics and Biomedicine
.

. - Machine Learning Models for Assessing Depression in Syrian Adolescent Refugees in Jordan.

. - Predicting T cell receptor specificity with graph attention networks.

. - CyberKnife and Data Mining: Exploring opportunities for clinical advancements.

. - Sickle cell disease patient care system using artificial intelligence.

. - Automated Annotation of Electronic Health Records Using Large Language Models.

. - A supervised learning strategy to investigate age effect on brain activity and support biomarkers detection for neurological disorders.

. -
Recent Advances in Bioinformatics
.

. - NucleoConvert Analytics: An Integrated Platform for DNA-to-RNA Conversion and Sequence Analysis.

. - Computational Analysis and Prediction of CYP1A2-Related Toxicants for Safer Drug Discovery.

. - Gene Co-Expression Network analysis based on GPUs for biomarkers discovery in sarcomas.

. - An Algorithm For Local Pairwise Alignment Of DNA Sequences.

. - Metabolomic Predictions via SOM: A Cold-Stress Case Study in Arabidopsis thaliana.