Genetically Engineered Mice for Cancer Research

Foreword. - Preface. - Overview of Designing Genetically-Engineered Mouse Models. - The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer. - Using Recombineering Technology To Create Genetically Engineered Mouse Models. - Insertional Mutagenesis for Generating Mouse Models of Cancer. - The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer. - Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat. - The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology. - Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer. - Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry. - Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing. - Imaging mouse models of human cancer. - Identifying Mammary Epithelial Stem and Progenitor Cells. - Differentiation Programs in Development and Cancer. - Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse. - Mouse Models for Colorectal Cancer. - Src family tyrosine kinases: Implications for mammary tumor progression. - Maspin and Suppression of Tumor Metastasis. - Epigenetic Mouse Models. - Modeling Transforming Growth Factor-ß Signaling in Cancer. - Modeling Stromal-Epithelial Interactions. - Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development. - Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models. - The Development and Use of Genetically Tractable Pre-Clinical Mouse Models. - Animal Models for Breast Cancer Prevention Resarch. - Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies. - Mouse Models in Preclinical Drug Development- Applications to CNS Models. - Mouse Models of Human Cancer: Role inPre-clinical Testing and Personalized Medicine. - Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development. - Index.