Molecular, Clinical and Environmental Toxicology

Historical milestones and discoveries that shaped the toxicology sciences. - Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment. - The role of biotransformation and bioactivation in toxicity. - Genotoxicity: damage to DNA and its consequences. - Role of DNA repair in the protection against genotoxic stress. - On the impact of the molecule structure in chemical carcinogenesis. - Chemical induced alterations in p53 signaling. - Molecular pathways involved in cell death after chemically induced DNA damage. - The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways. - Mapping the epigenome impact for toxicology. - Receptors mediating toxicity and their involvement in endocrine disruption. - Toxicogenomics: transcription profiling for toxicology assessment. - The role of toxicoproteomics in assessing organ specific toxicity. - High-throughput screening for analysis of in vitro toxicity.