Inositol and Phosphoinositides: Metabolism and Regulation

I: myo-Inositol Metabolism and Homeostasis.- The Mechanism of Enzymatic Isomerization of Glucose 6-Phosphate to L-myo-Inositol 1-Phosphate.- Regulation of the Lipid Composition of Lung Surfactant.- Nutritional Regulation of the Composition, Metabolism, and Function of Cellular Phosphatidylinositol.- Detection of Receptor-Linked Phosphoinositide Metabolism in Brain of Lithium-Treated Rats.- Propranolol-Induced Membrane Perturbation and the Metabolism of Phosphoinositides and Arachidonoyl Diacylglycerols in the Retina.- Neurotransmitter Receptor-Mediated myo-Inositol 1-Phosphate Accumulation in Hippocampal Slices.- Early Events in the Selective Cytotoxicity to Tumor Cells Induced by Liposomes Containing Plant Phosphatidylinositol.- Discussion.- II: Phosphoinositide Biosynthesis and Degradation.- Phosphatidylinositol Synthase in Mammalian Pancreas.- The Enzymology of Phosphoinositide Catabolism, with Particular Reference to Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase.- Subcellular Sites of Polyphosphoinositide Metabolism in Rat Liver.- Loss of Phosphatidylinositol and Gain in Phosphatidate in Neutrophils Stimulated with FMet-Leu-Phe.- The De Novo Phospholipid Synthesis Effect: Occurrence, Characteristics, Underlying Mechanisms, and Functional Significance in Hormone Action and Secretion.- Hydrolysis of Phosphatidylinositol 4-Phosphate and Phosphatidylinositol(4,5)-Bisphosphate by Specific Phosphomonoesterases in Human Erythrocytes.- Drug-Induced Modifications of Phosphoinositide Metabolism.- Discussion.- III: Receptor-Mediated Alterations in Phosphoinositide Metabolism.- Inositol Lipid Breakdown in Receptor-Mediated Responses of Sympathetic Ganglia and Sympathetically Innervated Tissues.- Hormone Effects on Phosphoinositide Metabolism in Liver.- Relationship Between Vasopressin Activation of Rat Hepatocyte Glycogen Phosphorylase, Inhibition of Ca2+-Mg2+-ATPase, and Phosphoinositide Breakdown.- Polyphosphoinositides and Muscarinic Cholinergic and ?1-Adrenergic Receptors in the Iris Smooth Muscle.- The Phosphatidylinositol Effect in the Retina: Role of Light and Neurotransmitters.- Ca2+-Mobilizing Agonists Stimulate a Polyphosphoinositide-Specific Phospholipase C in Rat Parotid Gland.- Phosphatidylinositol Degradation is Directly Proportional to the Rate of Cell Division in Embryonic Chicken Lens Epithelia.- Discussion.- IV: Phosphoinositides, Calcium, and Protein Phosphorylation.- Messages of the Phosphoinositide Effect.- Inositol Trisphosphate and Calcium Mobilization.- Calcium-Phosphatidylinositol Interactions in Secretory Cells and the Role of Arachidonic Acid.- Calcium and Inositol Phospholipid Degradation in Signal Transduction.- The Role of Phosphoprotein B-50 in Phosphoinositide Metabolism in Brain Synaptic Plasma Membranes.- Purification of Protein Kinase C and Phorbol Ester Receptor Using Polyacrylamide-Immobilized Phosphatidylserine.- Second Messenger Role of Inositol Trisphosphate for Mobilization of Intracellular Calcium in Liver.- Discussion.- V: Phosphoinositides and Arachidonic Acid Mobilization.- Mechanisms for Eicosanoid Precursor Uptake and Release by a Tissue Culture Cell Line.- The Mobilization of Arachidonate and Metabolism of Phosphoinositides in Stimulated Human Platelets.- The Relevance of Inositide Degradation and Protein Kinase C in Platelet Responses.- Regulation of Arachidonic Acid Release for Prostaglandin Production During Parturition.- Is Phosphatidylinositol Involved in the Release of Free Fatty Acids in Cerebral Ischemia?.- Endogenous Phospholipid Metabolism in Stimulated Human Platelets: A Link Between Inositide Breakdown and Calcium Mobilization.- Phosphatidylinositol Turnover in Madin-Darby Canine Kidney Cells: Comparison of Stimulation by A23187 and 12-O-Tetradecanoyl-Phorbol-13-Acetate.- Discussion.- VI: Phosphoinositide Metabolism in the Nervous System.- Inositol, Sorbitol, and Diabetic Neuropathy.- Altered Nerve myo-lnositol Metabolism in Experimental Diabetes and Its Relatio