Kinase inhibition remains an area of significant interest across academia and in the pharmaceutical industry. There are now many marketed drugs which target kinases and a significant number of compounds are currently in various stages of clinical development. Although there have been a number of publications on kinase inhibition, this is the first to examine the future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and focuses on a number of key areas for kinase inhibition over the coming years.
Inhaltsverzeichnis
An Introduction to Kinase Inhibition; The Kinome and its Impact on Medicinal Chemistry; Contemporary Approaches to Kinase Lead Generation; The Learning and Evolution of Medicinal Chemistry against Kinase Targets; The Mechanism and Kinetics of Kinase Inhibitors; Kinase mutations and resistance in cancer; Non-Protein Kinases as Therapeutic Targets; The Drug Discovery and Development of Kinase Inhibitors Outside of Oncology; Allosteric Activators of Glucokinase (GK) for the Treatment of Type 2 Diabetes; Drug Discovery and Non-Human Kinomes; The future of kinase drug discovery
