Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia.
The book will be structured in three main sections. The first section will introduce epigenetics and explain its importance at both a phenomenological and molecular level. The second section will go on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section will highlight the ongoing challenges in creating safe and efficacious epigenetic drugs.
Written and edited by experts within the field from both industry and academia, this book will provide an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.
Inhaltsverzeichnis
Epigenetics - What it is and Why it Matters; Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk; Epigenetics and Disease; Targeting DNA Methylation; Targeting Histone Acetylation; Targeting Histone Lysine Methyltransferases in Cancer; Targeting Non-Acetylation Histone Erasers; Progress in Targeting Epigenetic Readers; Who will Bebefit from Epigenetic Drugs; Dosing - When Less Is More; Histone Methyltransferase Activity Assays; Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?;
